Sildenafil works by inhibiting a specific enzyme called phosphodiesterase-5 (PDE5). This enzyme normally breaks down a crucial messenger molecule, cyclic guanosine monophosphate (cGMP).
CGMP’s Role in Erection
Increased cGMP levels in the smooth muscles of the penis’s blood vessels are vital for achieving and maintaining an erection. When sexually stimulated, nitric oxide is released, leading to increased cGMP production. This causes the blood vessels to relax and dilate, allowing increased blood flow into the penis.
Sildenafil’s Action
- By blocking PDE5, sildenafil prevents the breakdown of cGMP. Elevated cGMP levels persist, maintaining vasodilation. This prolonged vasodilation facilitates a stronger and longer-lasting erection.
It’s important to understand that sildenafil doesn’t directly cause an erection; it enhances the body’s natural response to sexual stimulation.
Factors Affecting Sildenafil’s Efficacy
Individual physiological variations influence the drug’s impact. Underlying health conditions may affect how well sildenafil works. Proper dosage and timing relative to sexual activity are crucial.
Potential Side Effects
Common side effects can include headaches, facial flushing, and nasal congestion. Less frequent but more serious side effects are possible and require immediate medical attention.
Consulting a Doctor
Always consult your doctor before using sildenafil. They can assess your health status and determine if it’s appropriate for you. They can also help manage potential side effects and interactions with other medications.
