Sildenafil citrate works by inhibiting a specific enzyme called phosphodiesterase-5 (PDE5). PDE5 breaks down cyclic guanosine monophosphate (cGMP), a crucial molecule for achieving and maintaining an erection. By blocking PDE5, sildenafil allows cGMP levels to rise. Increased cGMP relaxes the smooth muscles in the blood vessels of the penis, leading to increased blood flow. This increased blood flow is the key to achieving and sustaining an erection.
Absorption and Metabolism
Sildenafil is readily absorbed after oral administration. Peak plasma concentrations are typically reached within 30 to 120 minutes. The drug is extensively metabolized in the liver, primarily by the cytochrome P450 enzyme system. This means that medications that affect this enzyme system might influence sildenafil’s effects and duration. Consult your doctor regarding potential interactions with other drugs.
Factors Affecting Efficacy
Several factors affect sildenafil’s efficacy. These include the severity of erectile dysfunction, individual response, and the presence of underlying health conditions like heart disease or diabetes. Dosage adjustments might be necessary based on these individual factors. Always follow your doctor’s instructions regarding dosage and frequency of use.
