Prednisolone use in cirrhosis requires careful consideration. We recommend reserving it for specific, well-defined indications, primarily managing ascites refractory to standard therapy, and always in consultation with a hepatologist. Avoid routine use; its benefits are often outweighed by potential side effects.
Studies show Prednisolone can effectively reduce ascites volume in selected patients, improving their quality of life. However, remember that its efficacy varies significantly. Factors influencing response include the severity of liver disease, the presence of other complications like hepatic encephalopathy, and the patient’s overall health. Careful monitoring for adverse events is paramount.
Potential side effects include increased blood sugar, hypertension, and increased risk of infections. We strongly advise close monitoring of blood glucose levels and blood pressure throughout treatment. Regular assessments for signs of infection are also critical. Discontinue Prednisolone if significant adverse events occur. Alternative therapies should always be explored before initiating Prednisolone.
Dosage and duration should be individually tailored and closely supervised by a physician experienced in managing cirrhosis. There’s no one-size-fits-all approach. A systematic approach to managing ascites, prioritizing non-pharmacological measures and other medications, should always precede Prednisolone use. This nuanced approach is vital for optimal patient outcomes.
