The Mayo Clinic acknowledges metformin’s potential for weight loss, but emphasizes it’s not a primary weight-loss medication. They recommend it primarily for individuals with type 2 diabetes. Weight loss occurs as a side effect, often modest, typically around 2-5 pounds over several months. This weight reduction results from improved insulin sensitivity and reduced glucose production in the liver.
Individual responses vary significantly. Some patients experience notable weight loss, while others see minimal changes. Factors influencing results include diet, exercise, and overall health. The Clinic stresses the importance of combining metformin with lifestyle modifications like a balanced diet and regular physical activity to maximize weight loss benefits.
Before starting metformin, a consultation with a healthcare provider is necessary. They will assess your health status, evaluate potential risks and benefits, and monitor for side effects, which can include gastrointestinal issues (diarrhea, nausea) and vitamin B12 deficiency. Regular blood tests are often required to monitor kidney function and blood sugar levels.
The Mayo Clinic does not endorse metformin solely for weight loss. It’s a prescription medication, and its use should be guided by a doctor, considering individual health conditions and potential drug interactions. They recommend exploring other weight-loss strategies–particularly diet and exercise–as primary approaches. Metformin, when prescribed appropriately, can act as a supplementary tool for certain individuals.


