Sildenafil, the active ingredient in Vergara sildenafil 50 mg tablets, primarily targets a specific enzyme: phosphodiesterase-5 (PDE5). This enzyme breaks down cyclic guanosine monophosphate (cGMP), a crucial molecule in the penis’s erectile process.
By inhibiting PDE5, sildenafil allows cGMP levels to rise. Increased cGMP relaxes the smooth muscles in the blood vessels of the penis, resulting in increased blood flow. This enhanced blood flow is the key to achieving and maintaining an erection.
The process isn’t instantaneous. Sexual stimulation is still needed to trigger the release of nitric oxide, initiating the chain reaction that leads to cGMP production and, ultimately, penile erection.
Here’s a simplified overview:
| 1 | Sexual stimulation |
| 2 | Nitric oxide release |
| 3 | CGMP increase (Sildenafil prevents breakdown) |
| 4 | Smooth muscle relaxation |
| 5 | Increased blood flow to the penis |
| 6 | Erection |
Sildenafil’s impact is highly specific to PDE5. While it does affect other PDE enzymes to a lesser degree, this targeted action minimizes potential side effects.
