Avoid taking amoxicillin with anticoagulants like warfarin. Amoxicillin can increase the risk of bleeding by altering how your body processes warfarin. Closely monitor your INR levels if you’re on both medications.
Methotrexate is another drug to watch out for. Amoxicillin can boost methotrexate’s effects, potentially causing toxicity. Your doctor should monitor you carefully if you need both medications.
Allopurinol, used for gout, interacts with amoxicillin. The combination may increase your risk of skin rashes. Report any unusual skin reactions immediately.
Specific Drug Combinations Requiring Caution:
Consult your doctor or pharmacist before combining amoxicillin with any other medication, especially the following:
| Oral contraceptives | Many brands | Amoxicillin may reduce their effectiveness. Consider additional birth control methods. |
| Probenecid | Used for gout | Probenecid increases amoxicillin levels in your blood, potentially causing side effects. |
| Sulfonamides | Certain antibiotics | Combined use may increase the likelihood of certain side effects, especially skin reactions. |
Herbal Supplements and Alcohol:
Avoid alcohol while taking amoxicillin, as it can increase the risk of liver damage. Some herbal supplements may interact unpredictably with amoxicillin; always disclose your supplement use to your doctor or pharmacist.
