Always inform your veterinarian about all medications your cat is currently taking before administering azithromycin. This includes prescription drugs, over-the-counter medications, and even herbal supplements. Certain combinations can lead to unforeseen complications.
Avoid concurrent use with drugs that prolong the QT interval, such as some antiarrhythmics (like amiodarone or quinidine) or certain antipsychotics. This combination increases the risk of dangerous heart rhythm disturbances.
Azithromycin may interact negatively with ergot alkaloids, potentially causing peripheral vasoconstriction and ergotism. Consult your vet before using both.
Concurrent administration of azithromycin and medications metabolized by the liver, specifically through the cytochrome P450 system (CYP3A4), requires cautious monitoring. This can lead to increased or decreased levels of either drug in the bloodstream, altering their effectiveness or increasing the risk of side effects. Examples include some statins and antihistamines.
Antacids containing aluminum or magnesium can reduce azithromycin absorption, making the antibiotic less effective. Administer these medications at least two hours apart.
Finally, always follow your veterinarian’s instructions precisely regarding dosage and administration. They can provide personalized guidance based on your cat’s health status and other medications.
