Combining ketoconazole and prednisone requires careful monitoring due to potential interactions and increased risk of side effects. Ketoconazole inhibits the metabolism of prednisone, leading to higher prednisone levels in your blood. This can intensify prednisone’s effects, both positive and negative.
Increased Prednisone Effects:
- Elevated Blood Sugar: Monitor your blood glucose regularly. Your doctor may need to adjust your diabetes medication. Increased Risk of Infection: Prednisone suppresses your immune system. Be vigilant about hygiene and report any signs of infection immediately. Fluid Retention and Swelling: Watch for swelling in your ankles, feet, or legs. Reduce your salt intake. Increased Blood Pressure: Regular blood pressure checks are crucial. Your doctor might adjust your blood pressure medication. Gastrointestinal Issues: Stomach upset, heartburn, and ulcers are possible. Inform your doctor if you experience these symptoms.
Ketoconazole Side Effects (May be exacerbated by Prednisone):
- Liver Problems: Regular liver function tests are necessary. Report any signs of jaundice (yellowing of skin or eyes). Nausea and Vomiting: Take ketoconazole with food to minimize these effects.
Recommendations:
Regularly monitor your blood pressure, blood sugar, and liver function. Report any unusual symptoms to your doctor immediately. Discuss alternative antifungal medications with your physician if possible. Strictly adhere to your prescribed dosage and schedule for both medications. Never stop taking either medication without consulting your doctor.
This information is for educational purposes only and should not replace professional medical advice. Always consult your doctor or pharmacist before starting or changing any medications.
