Viagra, or sildenafil, works by inhibiting phosphodiesterase-5 (PDE5), an enzyme that breaks down cyclic GMP. Increased cyclic GMP relaxes blood vessels in the penis, allowing for improved blood flow and facilitating an erection. This is a simplified explanation, but it captures the core mechanism.
Several medications can interact with Viagra, sometimes dangerously. Nitrates, commonly used to treat angina, are a major concern. Combining them with Viagra can cause a significant drop in blood pressure, leading to dizziness, fainting, or even heart attack. Avoid this combination.
Alpha-blockers, prescribed for high blood pressure or benign prostatic hyperplasia (BPH), can also interact. The combined effect may lower blood pressure excessively. Your doctor should carefully monitor your blood pressure if you take both.
Certain antifungal medications, like ketoconazole and itraconazole, can increase Viagra’s levels in the blood, potentially intensifying side effects. HIV protease inhibitors, like ritonavir, have a similar effect. Your doctor may need to adjust your Viagra dosage.
Other medications, including some antibiotics and antidepressants, may also influence Viagra’s efficacy or side effects. Always inform your doctor and pharmacist of all medications you are taking, including over-the-counter drugs and supplements. This ensures safe and effective treatment. They can assess potential interactions and adjust medication accordingly.
Never self-adjust your medication dosage. This advice applies to all medications, not just Viagra. Consult your healthcare provider for any questions or concerns. They can offer personalized guidance based on your specific health status and medications.
