Tadalafil works by inhibiting a specific enzyme called phosphodiesterase-5 (PDE5). PDE5 normally breaks down cyclic guanosine monophosphate (cGMP), a molecule crucial for smooth muscle relaxation.
By blocking PDE5, tadalafil increases cGMP levels. Higher cGMP levels lead to relaxation of smooth muscles in the blood vessels of the penis, facilitating increased blood flow. This is the mechanism responsible for its effects on erectile function.
This process isn’t limited to the penis. Tadalafil’s effect on PDE5 also impacts other areas, contributing to its use in treating pulmonary hypertension, where it improves blood flow to the lungs.
The duration of tadalafil’s action is significantly longer than other similar medications due to its longer half-life. This allows for a more flexible dosing schedule.
It’s important to remember that tadalafil’s effectiveness depends on sexual stimulation. Tadalafil facilitates the physiological response to sexual arousal, but doesn’t create arousal itself.
