Tadalafil primarily works by inhibiting phosphodiesterase-5 (PDE5). This enzyme breaks down cyclic guanosine monophosphate (cGMP), a crucial molecule for blood vessel relaxation.
Here’s a simplified breakdown:
Sexual stimulation triggers the release of nitric oxide (NO). NO activates an enzyme called guanylate cyclase, which increases cGMP levels. Increased cGMP levels relax the smooth muscles in blood vessels, leading to increased blood flow. Tadalafil blocks PDE5, preventing the breakdown of cGMP. This prolonged elevation of cGMP sustains the vasodilation. The result is improved blood flow to the clitoris and surrounding tissues, potentially enhancing sexual responsiveness.
It’s important to note that Tadalafil doesn’t directly cause arousal; it enhances the physiological response to sexual stimulation.
- Individual responses to Tadalafil vary. Proper medical consultation before use is recommended. Always follow your doctor’s instructions and dosage recommendations.
While the primary mechanism focuses on blood flow, the exact impact on female sexual function is still under investigation. More research is needed to fully understand all aspects of Tadalafil’s effect in women.
