Sildenafil works by inhibiting phosphodiesterase-5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate (cGMP). Increased cGMP levels relax the smooth muscles in the blood vessels of the penis, allowing increased blood flow.
Increased Blood Flow and Erection
This enhanced blood flow is the key to achieving and maintaining an erection. The process begins with sexual stimulation, triggering the release of nitric oxide. Nitric oxide then stimulates the production of cGMP, leading to vasodilation (widening of blood vessels). Sildenafil’s inhibition of PDE5 prolongs the effects of cGMP, resulting in a stronger and more sustained erection.
Important Considerations
It’s vital to remember that sildenafil only works in the presence of sexual stimulation. It doesn’t create spontaneous erections. The drug’s effects vary depending on individual factors, including overall health and the severity of erectile dysfunction.
