Prednisone offers rapid allergy symptom relief, unlike many other allergy medications. However, it’s a steroid, requiring careful consideration due to potential side effects.
Antihistamines, like cetirizine or fexofenadine, provide milder, longer-lasting relief but may not be as potent for severe allergies. They’re generally well-tolerated.
Leukotriene modifiers, such as montelukast, target a different pathway in the allergic response. They’re useful for preventing allergy symptoms, particularly asthma related to allergies, but don’t offer immediate relief.
Decongestants, such as pseudoephedrine, alleviate nasal congestion, but prolonged use can cause rebound congestion. They’re best used short-term.
| Prednisone | Rapid | Short | Weight gain, mood changes, increased blood sugar | Severe, acute allergies |
| Antihistamines | Moderate | Long | Drowsiness (some formulations), dry mouth | Mild to moderate allergies |
| Leukotriene Modifiers | Slow | Long | Headache, diarrhea | Asthma and allergy prevention |
| Decongestants | Rapid | Short | Rebound congestion (with prolonged use), high blood pressure | Short-term nasal congestion relief |
Your doctor should guide you on the best medication based on your specific allergy symptoms, their severity, and your overall health. Always follow your doctor’s instructions regarding medication dosage and duration of treatment.


