Combining terazosin and sildenafil significantly increases the risk of severe hypotension, or dangerously low blood pressure. This effect stems from the fact that both medications lower blood pressure. Terazosin, an alpha-blocker, relaxes blood vessels, while sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, enhances nitric oxide’s vasodilatory effects.
Symptoms of severe hypotension include dizziness, lightheadedness, fainting, and potentially more serious complications. This interaction is particularly pronounced when starting or adjusting the dose of either medication.
Doctors often recommend careful monitoring of blood pressure, especially when initiating concurrent therapy. This may involve frequent blood pressure checks and a gradual increase in the dosage of either drug. Patients should report any dizziness or lightheadedness immediately to their physician.
Consider alternative treatments if the combined use is unavoidable. This might include adjusting dosages or substituting one medication with a drug possessing a different mechanism of action and a lower interaction risk.
Always inform your doctor about all medications you are taking, including over-the-counter drugs and supplements, to minimize potential drug interactions. Open communication with your healthcare provider is paramount for safe and effective treatment.
