Mixing methocarbamol with other drugs can be risky. Always talk to your doctor before combining medications.
Certain combinations can significantly increase drowsiness. This includes opioids (like oxycodone or hydrocodone), benzodiazepines (like diazepam or alprazolam), and other muscle relaxants. Driving or operating machinery becomes extremely dangerous under these circumstances.
Methocarbamol’s interaction with alcohol intensifies its sedative effects, potentially leading to severe respiratory depression. Avoid alcohol consumption entirely while taking methocarbamol.
Some medications can affect how your body processes methocarbamol. This includes medications metabolized by the liver, potentially altering methocarbamol levels in your blood. Examples include certain antidepressants and anti-anxiety medications.
| Opioids | Increased sedation, respiratory depression | Avoid combination unless explicitly prescribed |
| Benzodiazepines | Increased sedation, impaired coordination | Increased risk of falls and accidents |
| Alcohol | Severe sedation, respiratory depression | Avoid alcohol completely while on methocarbamol |
| CYP2C19 inhibitors (e. g., some antidepressants) | Increased methocarbamol levels | May require dosage adjustment |
This table provides a general overview. Specific interactions depend on individual factors like dosage, other health conditions, and other drugs taken. Consult your healthcare provider for personalized advice.
