Lisinopril directly inhibits angiotensin-converting enzyme (ACE). This enzyme plays a key role in the renin-angiotensin-aldosterone system (RAAS), a hormonal system regulating blood pressure and fluid balance. By blocking ACE, lisinopril prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Reduced angiotensin II leads to vasodilation, lowering blood pressure.
Reduced Vasoconstriction and Aldosterone
The decrease in angiotensin II also reduces aldosterone secretion. Aldosterone promotes sodium and water retention, contributing to increased blood volume and pressure. Lower aldosterone levels therefore contribute to lisinopril’s hypotensive effect by promoting sodium and water excretion.
Key Differences from Benazepril
Both lisinopril and benazepril are ACE inhibitors, but subtle differences exist. Lisinopril offers a longer half-life, meaning fewer daily doses might suffice. Additionally, individual patient responses vary; some individuals may experience better blood pressure control with one drug over the other.
Individualized Approach
Remember: dosage and choice between lisinopril and benazepril depend entirely on individual patient factors and require a physician’s assessment. Always consult your doctor before adjusting medication or choosing between these drugs.
