Avoid ibuprofen with blood thinners like warfarin or aspirin, as this combination increases bleeding risk. Simultaneous use may require dosage adjustments or careful monitoring by your doctor.
Ibuprofen can interact negatively with certain antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). This combination may increase the risk of bleeding and gastrointestinal issues. Consult your physician before combining these medications.
Specific Medications to Note:
Lithium levels can be affected by ibuprofen, leading to potential toxicity. Methyldopa, used for high blood pressure, may also interact, potentially reducing its effectiveness. Cyclosporine, commonly used in organ transplant patients, should not be combined with ibuprofen without close medical supervision, due to the increased risk of kidney damage.
Always inform your doctor or pharmacist about all medications, supplements, and herbal remedies you are taking before starting ibuprofen. This ensures they can assess potential interactions and help you manage them safely. This includes over-the-counter drugs and prescription medications. Failure to do so could lead to adverse health consequences.


