Interaction with Other Medications and Substances

Always inform your doctor about all medications you are currently taking, including over-the-counter drugs, supplements, and herbal remedies. This is crucial for safe sildenafil use. Some medications can significantly interact with sildenafil, potentially leading to dangerous side effects or reduced effectiveness.

Nitrates, commonly used to treat angina (chest pain), are particularly dangerous when combined with sildenafil. This combination can cause a dramatic drop in blood pressure, leading to dizziness, fainting, or even heart attack. Avoid using sildenafil if you are taking nitrates.

Alpha-blockers, prescribed for high blood pressure or benign prostatic hyperplasia (BPH), can also interact with sildenafil, increasing the risk of low blood pressure. Your doctor might adjust your dosages or recommend alternative treatments.

Certain antifungal medications, like ketoconazole and itraconazole, can increase sildenafil levels in your body, potentially intensifying side effects. Similarly, protease inhibitors used to treat HIV can also elevate sildenafil levels. Discuss these interactions with your physician.

Grapefruit juice contains compounds that can inhibit the metabolism of sildenafil, increasing its concentration in your blood. Limit grapefruit juice consumption while taking sildenafil.

Alcohol can exacerbate sildenafil’s side effects, such as dizziness and headaches. Moderate alcohol intake is recommended while using this medication. Always follow your doctor’s instructions and prioritize safety.