Doxycycline’s efficacy varies depending on the Plasmodium species causing the malaria infection. Against Plasmodium falciparum, the most dangerous malaria parasite, doxycycline provides prophylaxis, though its effectiveness is not absolute. Resistance to doxycycline is emerging, particularly in Southeast Asia, impacting its reliability.
Plasmodium vivax and Plasmodium ovale
Doxycycline is generally considered less effective against Plasmodium vivax and Plasmodium ovale compared to P. falciparum. These parasites have a liver stage, and doxycycline doesn’t completely eliminate this stage, leading to relapses after treatment. Consequently, doxycycline alone isn’t the recommended preventative measure for these species; other antimalarials are often preferred.
Plasmodium malariae
Doxycycline shows moderate effectiveness against Plasmodium malariae. However, due to the potential for resistance and the availability of other, arguably more suitable drugs, it’s rarely the first-line prophylaxis for this parasite. Always consult guidelines and local expertise for accurate recommendations regarding malaria prevention.
