Mupirocin generally shows stronger activity against Staphylococcus aureus, a common culprit in skin infections like impetigo. Polysporin, a bacitracin-polymyxin combination, demonstrates broader activity against Gram-negative bacteria, making it suitable for infections involving organisms like Pseudomonas aeruginosa. The best choice hinges on the suspected pathogen.
Identifying the Infection
Accurate diagnosis is key. A doctor can identify the bacteria causing your infection through a culture. This helps determine the most appropriate treatment. Self-treating can delay proper care. If your infection worsens or doesn’t improve after a few days, seek medical advice.
Specific Infection Examples
For example, impetigo, frequently caused by Staphylococcus aureus, often responds well to mupirocin. However, if you suspect an infection caused by a different bacterium, or if you have a more serious infection, polysporin might be less effective. Consult a physician for guidance on the most appropriate antibiotic choice.


