Drug Interactions: Medications to Avoid While Taking Naltrexone HCL

Avoid opioid pain medications like oxycodone, morphine, or codeine. Naltrexone blocks the effects of these opioids, leading to a lack of pain relief and potentially dangerous withdrawal symptoms. This interaction is serious and requires immediate medical attention if it occurs.

Refrain from combining naltrexone with other medications that affect the liver. This includes certain antidepressants and anti-anxiety drugs. These medications can increase the risk of liver damage when taken concurrently with naltrexone. Always inform your doctor about all medications you are taking.

Do not consume alcohol while on naltrexone. The combination can increase the risk of liver damage and may worsen the side effects of both substances. Even small amounts of alcohol should be avoided.

Be cautious with certain medications used to treat anxiety or sleep disorders, like benzodiazepines. Consult your doctor before combining these with naltrexone; potential interactions may necessitate dosage adjustments or alternative treatment plans.

Certain medications metabolized by the same liver enzymes as naltrexone can lead to altered drug levels. This includes some antipsychotics and certain antibiotics. Discuss these medications with your doctor or pharmacist to assess potential interactions and manage risks accordingly.

This list is not exhaustive. Always provide your doctor or pharmacist with a complete list of all medications, supplements, and herbal remedies you are taking. They can help identify any potential interactions and guide you on safe medication practices.