Tranexamic acid (TXA) is typically administered intravenously (IV) or orally. The choice depends on the specific surgical procedure and the patient’s condition.
IV Administration: A common protocol involves a bolus dose of 1 gram followed by an infusion of 1 gram over 8 hours. Adjustments may be necessary based on the patient’s bleeding risk and response. Always refer to the specific guidelines for your institution and the particular surgical procedure.
- Total Hip Arthroplasty: A common regimen involves a 1g IV bolus followed by an 8-hour infusion of 1g. Post-operative administration protocols vary widely between institutions and should be followed closely. Total Knee Arthroplasty: Similar to hip arthroplasty, a 1g IV bolus followed by a 1g 8-hour infusion is frequently employed. Always check the current practice at your facility. Other Orthopedic Procedures: Dosage and administration schedules vary depending on the procedure, bleeding risk, and patient characteristics. Consult relevant surgical guidelines.
Oral Administration: Oral TXA is often used as a prophylactic measure or in cases where IV administration is not feasible. Dosage typically ranges from 1-1.5 grams three times daily, but this varies significantly depending on patient factors and the specific surgical protocol. Always follow established guidelines.
Timing: For both IV and oral administration, precisely timed administration is vital for optimal efficacy. Monitoring: Close monitoring for adverse effects, such as thromboembolic events, is necessary. Report any unusual symptoms promptly. Contraindications: Be aware of contraindications such as active thromboembolic disease or a history of seizures. Always verify that there are no contraindications before prescribing TXA.
Remember, these are general guidelines. Always consult the most current evidence-based guidelines and your institution’s protocols to determine the appropriate dosage and administration method for each individual patient. Patient-specific factors heavily influence treatment decisions.
