Yes, lisinopril and indomethacin can interact, potentially reducing the effectiveness of lisinopril in lowering blood pressure. This interaction stems from indomethacin’s impact on the kidneys’ ability to excrete sodium and water, actions that counter lisinopril’s effects.
Specifically, indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), inhibits the production of prostaglandins. These prostaglandins play a crucial role in regulating kidney function, and their suppression by indomethacin can lead to fluid retention and increased blood pressure. Since lisinopril works by reducing blood pressure through vasodilation and sodium excretion, this counteraction diminishes its efficacy.
Consequently, combining these medications may require close monitoring of your blood pressure. Your doctor might adjust your lisinopril dosage or suggest alternative pain management strategies. Open communication with your healthcare provider is paramount to ensure your safety and optimal treatment plan. Regular blood pressure checks are recommended, especially when starting or changing medications like these.
