Cialis, containing tadalafil, works by inhibiting a specific enzyme called phosphodiesterase-5 (PDE5). This enzyme breaks down cyclic guanosine monophosphate (cGMP), a molecule crucial for smooth muscle relaxation in the penis.
By blocking PDE5, tadalafil increases cGMP levels. Higher cGMP levels promote relaxation of smooth muscles in the blood vessels supplying the penis, leading to increased blood flow.
This enhanced blood flow is responsible for achieving and maintaining an erection. The effect is triggered by sexual stimulation; Cialis doesn’t cause erections without sexual stimulation.
Tadalafil’s longer half-life, compared to other PDE5 inhibitors, allows for a more prolonged effect, lasting up to 36 hours. This extended duration distinguishes it from other medications in its class.
| Target Enzyme | Phosphodiesterase-5 (PDE5) |
| Mechanism | Inhibition of PDE5, leading to increased cGMP |
| Result | Relaxation of penile smooth muscles, increased blood flow |
| Duration of Effect | Up to 36 hours |
Remember to consult a healthcare professional before using Cialis or any medication, especially if you have underlying health conditions or are taking other medications. They can assess your suitability and provide personalized advice.
