The half-life of Benadryl citrate (diphenhydramine citrate) is approximately 2.5 to 4 hours. This means that half the drug is eliminated from your system within that timeframe.
However, individual responses vary. Factors like age, metabolism, and liver function influence how quickly your body processes Benadryl. Older adults, for example, often experience a longer half-life due to slower metabolic rates. This can lead to prolonged effects or increased risk of side effects.
Always follow your doctor’s or pharmacist’s instructions regarding dosage and frequency. Never exceed the recommended dose, as this can increase the risk of adverse reactions such as drowsiness, dizziness, and dry mouth. If you experience any concerning side effects, contact a healthcare professional immediately.
